< Rejuran vs PRF Melbourne | Which is right for you | BYGOLDEN Parkdale
Cosmetic medicine consultation at BYGOLDEN clinic in Parkdale, Melbourne

Cosmetic Medicine · BYGOLDEN Melbourne

Rejuran
or PRF

Two regenerative treatments, two different approaches, one shared goal. Here is how they compare, and how to find your starting point at BYGOLDEN in Parkdale.

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How they compare
Nurse and paramedic led
Doctor assessed
3D skin imaging
Parkdale, Melbourne
Two
Pathways to skin
renewal from within
One
Consultation to
find your starting point
The short version

Same intention,
different mechanism.

BYGOLDEN client at the Parkdale Melbourne clinic

Rejuran and PRF are both regenerative injectables. Rather than adding volume or resurfacing the skin from the outside, both work beneath the surface to support your skin's own repair processes.

Where they differ is in what is introduced. Rejuran uses highly purified polynucleotides to support cellular repair and skin quality. PRF is prepared from a small sample of your own blood, releasing growth factors gradually over the days that follow.

Neither is universally better. The right choice depends on your skin, your concerns and your preferences, which is why a consultation comes first.

Side by side

How they compare

A clear look at what sets each treatment apart, so you can arrive at your consultation with the right questions.

Treatment one
Rejuran
What it is
A regenerative injectable using highly purified polynucleotides.
Source
Polynucleotides, a laboratory-purified biological material.
How it works
Supports cellular repair and collagen production, working from within the skin.
May assist with
Skin texture, firmness, the appearance of pores and overall skin quality.
Treatment course
Typically a course of sessions, with results building progressively.
Downtime
Minimal. Some redness or small raised areas may be present briefly.
Treatment two
PRF
What it is
A regenerative injectable prepared from a small sample of your own blood.
Source
Your own biology, with nothing synthetic introduced.
How it works
A fibrin scaffold releases growth factors gradually to support skin renewal.
May assist with
Skin quality, the under eye area and, in some cases, hair restoration support.
Treatment course
Typically a course of sessions, with results developing over time.
Downtime
Minimal. Some redness or swelling may be present briefly.
Rejuran polynucleotide treatment at BYGOLDEN Parkdale Melbourne
A closer look

Rejuran

Rejuran works with your skin's own biology, using highly purified polynucleotides to support cellular repair and collagen production from within.

Rather than treating the surface alone, it addresses the underlying factors behind rough texture, loss of firmness and tired-looking skin. Results are not designed to peak and fade. They tend to build with each session.

  • Best considered where overall skin quality and texture are the priority
  • Supports firmness and a smoother appearance over a course
  • Administered via fine injections following numbing
Read more about Rejuran
PRF platelet rich fibrin treatment at BYGOLDEN Parkdale Melbourne
A closer look

PRF

PRF, or Platelet Rich Fibrin, is prepared from a small sample of your own blood. It is processed to concentrate platelets and fibrin, then reintroduced to the areas being treated.

The fibrin scaffold releases growth factors gradually, supporting collagen and skin renewal over the days that follow. Because it is entirely autologous, it appeals to those who prefer to work only with their own biology.

  • Often considered for the under eye area and skin quality
  • A fully autologous option, drawn from your own blood
  • May also be used as part of a structured hair restoration pathway
Read more about PRF
Finding your starting point

Which may suit you

01

Rejuran may suit you if

Your focus is overall skin quality, texture and firmness, and you are looking for a treatment that builds measurable improvement across a structured course.
02

PRF may suit you if

You prefer a fully autologous treatment using only your own biology, or your interest lies in the under eye area or hair restoration support.
03

A combined approach may suit you if

Your concerns span more than one area. In some cases a staged pathway drawing on both treatments may be considered, assessed individually.

These are general guides only. Your clinician will recommend the most appropriate approach for you at your consultation.

What to expect

Both treatments begin the same way

01
Consultation
A Cosmetic Medicine Consultation with our clinicians. We discuss your goals, medical history and what matters to you. No pressure, no scripts.
02
3D imaging
We capture a 3D baseline of your skin so every change can be measured against where you started. Progress is tracked, not guessed.
03
Doctor assessment
One of our doctors assesses suitability and recommends the most appropriate treatment for you, whether that is Rejuran, PRF or a combination.
04
Treatment
If treatment is right for you, it may begin at the same appointment. Your clinician will outline a plan tailored to your goals.
Regenerative treatment at BYGOLDEN Parkdale Melbourne
Your questions

Frequently asked questions

Rejuran uses highly purified polynucleotides to support cellular repair and skin quality, while PRF is prepared from a small sample of your own blood and releases growth factors over time. Both are regenerative injectables, but they work through different pathways and may suit different concerns.
In some cases a combined or staged approach may be appropriate. This is assessed individually during your Cosmetic Medicine Consultation, where your clinician will consider your skin, your goals and your history before recommending a pathway.
Both treatments involve fine injections and are associated with minimal downtime. Some redness, swelling or small raised areas may be present for a short period afterwards. Your clinician will discuss what to expect for your individual treatment.
The right starting point depends on your skin, your concerns and your preferences. A Cosmetic Medicine Consultation with assessment and 3D imaging allows your clinician to recommend the most suitable approach for you.
PRF, or Platelet Rich Fibrin, is a more recent generation of the same family of treatments. It is processed differently to form a fibrin scaffold that releases growth factors more gradually. Your clinician can explain the distinction in the context of your treatment.
At BYGOLDEN in Parkdale, Melbourne, our cosmetic medicine clinicians are Advanced Life Support Registered Nurses (RN1) and Paramedics. During your first appointment you will complete a consent process with our medical professionals and speak with one of our doctors, who will assess suitability and prescribe where appropriate.
You may also consider

Related treatments

Collagen stimulation
An injectable treatment that supports your skin's own collagen production, with results that build gradually and may last 18 to 24+ months.
Explore →
Bio-remodelling
An intensely hydrating injectable treatment that may assist skin quality and firmness across the face, neck and décolletage.
Explore →
Ready to begin

Start with a consultation

Both treatments begin the same way. A considered conversation, a thorough assessment and a recommendation built around your skin. If treatment is right for you, it can begin at the same appointment.

Book a cosmetic consultation→ Call 03 7047 7704
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BYGOLDEN · 230 Como Parade West, Parkdale VIC 3195
(03) 7047 7704 · team@bygolden.com.au
At a glance
Consultation requiredCosmetic Medicine
Treatment typeRegenerative injectable
SessionsCourse, tailored to you
DowntimeMinimal
Imaging3D skin assessment

Individual results may vary. All treatments at BYGOLDEN are subject to a consultation to determine suitability. Regenerative injectable treatments require doctor assessment and prescription where applicable. The information on this page is general in nature and does not constitute medical advice. Last reviewed June 2026.

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By Golden

Melbourne's cosmetic and skin clinic. Medical expertise guiding every step toward balanced, natural results.

230 Como Pde West
Parkdale VIC 3195


(03) 7047 7704
team@bygolden.com.au
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